整合素连接激酶ILK抗体
规格：1mg/1ml
英文名： Integrin linked ILK
别名： 59 kDa serine/threonine protein kinase; 59 kDa serine/threonine-protein kinase; DKFZp686F1765; ILK 1; ILK 2; ILK; ILK-1; ILK-2; ILK_HUMAN; ILK1; ILK2; Integrin linked kinase 2; Integrin linked Kinase;
分子量： 51kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Integrin
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
整合素连接激酶ILK抗体产品介绍：background: This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013] Function: Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway.整合素连接激酶ILK抗体 Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. Subcellular Location: Cell junction > focal adhesion. Cell membrane. Tissue Specificity: Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver. Post-translational modifications: Autophosphorylated on serine residues. Similarity: Belongs to the protein kinase superfamily整合素连接激酶ILK抗体. TKL Ser/Thr protein kinase family. Contains 5 ANK repeats. Contains 1 protein kinase domain. Gene ID: 3611 Database links: Entrez Gene: 3611 Human Entrez Gene: 16202 Mouse Entrez Gene: 170922 Rat Omim: 602366 Human SwissProt: Q13418 Human SwissProt: O55222 Mouse SwissProt: Q99J82 Rat Unigene: 5158 Human Unigene: 706355 Human Unigene: 274846 Mouse Unigene: 95042 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
整合素连接激酶ILK抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid