白细胞介素增强子结合因子3抗体
规格：1mg/1ml
英文名： ILF3
别名： CBTF; Double stranded RNA binding protein 76; Double-stranded RNA-binding protein 76; DRBF; DRBP76; ILF3; ILF3_HUMAN; Interleukin enhancer binding factor 3; Interleukin enhancer-binding factor 3; M ph
分子量： 95kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ILF3
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
细胞定位：细胞核
白细胞介素增强子结合因子3抗体产品介绍：background: This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2008] Function: May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of 白细胞介素增强子结合因子3抗体acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Subcellular Location: Nucleus; nucleolus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Tissue Specificity: Ubiquitous. Post-translational modifications: Phosphorylated by RNA-dependent protein kinase (EIF2AK2). Methylated by protein arginine N-methyltransferase 1. Arg-609 is 白细胞介素增强子结合因子3抗体dimethylated, probably to asymmetric dimethylarginine. Similarity: Contains 2 DRBM (double-stranded RNA-binding) domains. Contains 1 DZF domain. Gene ID: 3609 Database links: Entrez Gene: 3609 Human Entrez Gene: 614936 Cow Entrez Gene: 16201 Mouse Entrez Gene: 84472 Rat Entrez Gene: 321868 Zebrafish Omim: 603182 Human SwissProt: Q12906 Human SwissProt: Q9Z1X4 Mouse SwissProt: Q9JIL3 Rat SwissProt: Q6NXA4 Zebrafish Unigene: 465885 Human Unigene: 440026 Mouse Unigene: 203881 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
白细胞介素增强子结合因子3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 转运蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid