TRAP100蛋白抗体
规格：1mg/1ml
英文名： TRAP100
别名： Activator recruited cofactor 100 kDa component; ARC100; Cofactor required for Sp1 transcriptional activation subunit 4; CRSP complex subunit 4; CRSP100; CRSP4; DRIP100; hTRAP100; KIAA0130; MED24_HUMAN
分子量： 110kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TRAP100
交叉反应：Human, Mouse, Rat, Chicken, Rhesus monkey, Gorilla, Orangutan
细胞定位：细胞核
TRAP100蛋白抗体产品介绍：background: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: TRAP100 plays a role in transcriptional coactivation. It plays a role in nuclear hormone receptor mediated transactivation. TRAP100 is a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to TRAP100蛋白抗体induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre initiation complex. Subunit: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator TRAP100蛋白抗体complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR. Subcellular Location: Nuclear Tissue Specificity: Ubiquitous. Abundant in skeletal muscle, heart and placenta. Similarity: Belongs to the Mediator complex subunit 24 family. Gene ID: 9862 Database links: Entrez Gene: 9862 Human Entrez Gene: 426134 Chicken Entrez Gene: 480529 Dog Entrez Gene: 23989 Mouse Entrez Gene: 619436 Rat Omim: 607000 Human SwissProt: Q5F3M0 Chicken SwissProt: O75448 Human SwissProt: Q99K74 Mouse SwissProt: Q4V8B3 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TRAP100蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid