延伸因子4抗体
规格：1mg/1ml
英文名： Translation factor GUF1
别名： EF-4; Elongation factor 4 homolog; GTPase GUF1; GUF1; GUF1_HUMAN; mitochondrial; Ribosomal back-translocase; Translation factor guf1.
分子量： 69kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Translat
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Zebrafish, Sheep,
细胞定位：
延伸因子4抗体产品介绍：background: GUF1 is a 669 amino acid protein belonging to the GTP-binding elongation factor family and the LepA subfamily. Localizing to the mitochondrion inner membrane, GUF1 is thought to promote mitochondrial protein synthesis and binds to mitochondrial ribosomes in a GTP-dependent manner. GUF1 is suggested to catalyze a one-codon backward translocation of tRNAs on improperly translocated ribosomes, thereby acting as a fidelity factor of the translation reaction. GUF1 is encoded by a gene located on human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene desert (regions of the genome with no protein encoding genes)延伸因子4抗体 of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. Function: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly 延伸因子4抗体translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. Subcellular Location: Mitochondrion inner membrane. Similarity: Belongs to the GTP-binding elongation factor family. LepA subfamily. Gene ID: 60558 Database links: Entrez Gene: 60558 Human SwissProt: Q8N442 Human Unigene: 546419 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
延伸因子4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid