磷酸化肝细胞生长调节因子酪氨酸激酶底物抗体
规格：1mg/1ml
英文名： phospho-HGS (Tyr334)
别名： HGS (phospho Y334); p-HGS (phospho Y334); Hepatocyte growth factor regulated tyrosine kinase substrate; Hepatocyte growth factor-regulated tyrosine kinase substrate; HGF-regulated tyrosine kinase subs
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
磷酸化肝细胞生长调节因子酪氨酸激酶底物抗体产品介绍：background: HGS is a regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]. Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the 磷酸化肝细胞生长调节因子酪氨酸激酶底物抗体efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. Subcellular Location: Cytoplasm. Early endosome membrane. Endosome > multivesicular body membrane. Tissue Specificity: Ubiquitous expression in ***** and fetal tissues with higher expression in testis and peripheral blood leukocytes. Post-translational modifications: Phosphorylated on Tyr-334. 磷酸化肝细胞生长调节因子酪氨酸激酶底物抗体A minor site of phosphorylation on Tyr-329 is detected (By similarity). Phosphorylation occurs in response to EGF, IL-2, GM-CSF and HGF. Ubiquitinated by ITCH. Similarity: Contains 1 FYVE-type zinc finger. Contains 1 UIM (ubiquitin-interacting motif) repeat. Contains 1 VHS domain. Database links: Entrez Gene: 9146 Human Entrez Gene: 15239 Mouse Omim: 604375 Human SwissProt: O14964 Human SwissProt: Q99LI8 Mouse Unigene: 514590 Human Unigene: 7919 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化肝细胞生长调节因子酪氨酸激酶底物抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid