ZRANB1蛋白抗体
规格：1mg/1ml
英文名： ZRANB1
别名： DKFZp762P2216; hTrabid; Trabid; TRAF-binding protein domain; Ubiquitin thioesterase ZRANB1; Zinc finger Ran-binding domain-containing protein 1; ZRAN1_HUMAN; ZRANB1.
分子量： 81kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ZRANB1
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：细胞核 细胞浆
ZRANB1蛋白抗体产品介绍：background: TRABID is a 708 amino acid cytoplasmic and nuclear protein that is widely expressed. Belonging to the peptidase C64 family, TRABID is considered a positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. TRABID acts by deubiquitinating APC, a negative regulator of Wnt-mediated transcription. TRABID contains a OTU domain, which mediates the deubiquitinating activity, and three RanBP2-type zinc fingers that mediate the specific interaction with 'Lys-63'-linked ubiquitin. It is suggested that TRABID may also modulate TNF?signaling. The gene encoding TRABID is located on chromosome 10, whichZRANB1蛋白抗体 houses over 1,200 genes and comprises nearly 4.5% of the human genome. Function: Positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. Acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription. May also modulate TNF-alpha signaling. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Widely expressed. Similarity: Belongs to the peptidase C64 family. Contains 1 OTU domain. Contains 3 RanBP2-type zinc fingers. Gene ID: 54764 Database links: Entrez Gene: 54764 ZRANB1蛋白抗体Human Entrez Gene: 360216 Mouse Omim: 611749 Human SwissProt: Q9UGI0 Human SwissProt: Q7M760 Mouse Unigene: 595158 Human Unigene: 389984 Mouse Unigene: 397069 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ZRANB1蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 表观遗传学 泛素
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid