HA1蛋白抗体
规格：1mg/1ml
英文名： HA1
别名： HLA HA1; HMHA1_HUMAN; HMHA1; KIAA0223; mHag HA-1; Minor histocompatibility antigen HA 1; Minor histocompatibility protein HA 1.
分子量： 125kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HA1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
细胞定位：细胞浆
HA1蛋白抗体产品介绍：background: Major histocompatibility complex (MHC) molecules, which include human leukocyte antigens (HLAs), form an integral part of the immune response system. They are cell-surface receptors that bind foreign peptides and present them to cytotoxic T lymphocytes (CTLs). Minor histocompatibility antigens can form an immune response upon recognition by certain T-cells when complexed with MHC molecules. HA-1 (minor histocompatibility protein HA-1), also known as HA-1, HLA-HA1 or HMHA1, is a 1,136 amino acid GTPase activator of Rho-type GTPases. Expressed in dendritic cells, epidermal Langerhans cells, hematopoietic cells, peripheral blood mononuclear cells and all leukemia and lymphoma cell lines, HA-1 is also found in various solid tissues and tumors. Highly phosphorylated, HA-1 contains one HA1蛋白抗体Rho-GAP domain, a single phorbol-ester/DAG-type zinc finger and is encoded by a gene located on human chromosome 19p13.3. Function: The minor histocompatibility antigen (mHags), HA-1 is a immunogenic alloantigen shown to be responsible for graft-versus-host disease (GVHD) in HLA-identical bone marrow transplantation. The antigen has two known alleles resulting in a single amino acid polymorphism. The HA-1H allele encodes histidine, whereas the HA-1R allele encodes arginine. Subunit: HA-1 forms a complex with MHC class I HLA-A*0201. Subcellular Location: Cytoplasmic HA1蛋白抗体Tissue Specificity: Expressed on cells of the hematopoietic lineage. Detected in dendritic cells and epidermal Langerhans cells. Expressed in peripheral blood mononuclear cells, in all leukemia/lymphoma cell lines. Detected also in some solid tumors and tissues such as cancerous and non-cancerous tissue Similarity: Contains 1 phorbol-ester/DAG-type zinc finger. Contains 1 Rho-GAP domain. Gene ID: 23526 Database links: Entrez Gene: 23526 Human Entrez Gene: 70719 Mouse Entrez Gene: 314618 Rat Omim: 601155 Human SwissProt: Q92619 Human SwissProt: Q3TBD2 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
HA1蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 转运蛋白 **细胞 t-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid