通用转录因子3C多肽4/TFIIIC90抗体
规格：1mg/1ml
英文名： GTF3C4
别名： EC 2.3.1.48; FLJ21002; General transcription factor 3C 4; General transcription factor 3C polypeptide 4; General transcription factor IIIC, polypeptide 4, 90kDa; GTF3C4; KAT12; MGC138450; OTTHUMP00000
分子量： 92kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GTF3C4
交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit,
细胞定位：细胞核
通用转录因子3C多肽4/TFIIIC90抗体产品介绍：background: RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB’’, the expression of which are also upregulated in transformed cells通用转录因子3C多肽4/TFIIIC90抗体. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB. Function: Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity 通用转录因子3C多肽4/TFIIIC90抗体(HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box. Subcellular Location: Nucleus. Similarity: Belongs to the TFIIIC subunit 4 family. Gene ID: 9329 Database links: Entrez Gene: 9329 Human Entrez Gene: 269252 Mouse Entrez Gene: 685539 Rat Omim: 604892 Human SwissProt: Q9UKN8 Human SwissProt: Q8BMQ2 Mouse Unigene: 656646 Human Unigene: 26043 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
通用转录因子3C多肽4/TFIIIC90抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid