谷氨酸受体亚基δ2/GluR-δ2抗体
规格：1mg/1ml
英文名： GRID2
别名： GLUR D2; GluR delta 2; GLURD 2; GRID2_HUMAN; GLURD2; Glutamate receptor delta 2 subunit; Glutamate receptor ionotropic delta 2; GRID 2; MGC117022; MGC117023; MGC117024.
分子量： 110kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GRID2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
谷氨酸受体亚基δ2/GluR-δ2抗体产品介绍：background: The protein encoded by this gene is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for this gene in neuronal apoptotic death. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013] Function: Glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory 谷氨酸受体亚基δ2/GluR-δ2抗体neurotransmitter receptors in the mammalian brain. Mouse GRID2 is expressed selectively in cerebellar Purkinje cells. A point mutation in mouse GRID2, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This strongly suggests a role for GRID2 in neuronal apoptotic death. Subunit: Interacts with AIP1, AP4M1, BECN1, GOPC, GRID2IP, SHANK1 and SHANK2 (By similarity). Interacts with CBLN1 and CBLN2, but not with 谷氨酸受体亚基δ2/GluR-δ2抗体CBLN4. CBLN1-binding is calcium-independent (By similarity). Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID2 subfamily. Gene ID: 2895 Database links: Entrez Gene: 2895 Human Entrez Gene: 14804 Mouse Entrez Gene: 79220 Rat Omim: 602368 Human SwissProt: O43424 Human SwissProt: Q61625 Mouse SwissProt: Q63226 Rat Unigene: 480281 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
谷氨酸受体亚基δ2/GluR-δ2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 神经生物学 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid