G蛋白偶联受体73A抗体
规格：1mg/1ml
英文名： GPR73A
别名： EG-VEGF receptor; G protein coupled receptor 73; G protein coupled receptor ZAQ; G-protein coupled receptor 73; G-protein coupled receptor ZAQ; GPR73; GPR73a; PK R1; PK-R1; PKR1; PKR1_HUMAN; Prokineti
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GPR73A
交叉反应：Human, Dog, Cow,
细胞定位：细胞膜
G蛋白偶联受体73A抗体产品介绍：background: The prokineticin receptors, PKR1 (GPR73a) and PKR2 (GPR73b), are G protein-coupled receptors responsible for mediating the signal transduction of both EG-VEGF and Prokineticin-2. PKR1 and PKR2 share 87% sequence identity. PKR1 is predominantly expressed in the peripheral tissues and PKR2 is typically expressed in the CNS. Both receptors are found in the testis. Upon ligand binding, PKR1 and PKR2 associate with G protein and can promote intracellular calcium mobilization, stimulate phosphoinositide turnover and activate the MAPK pathway. These receptors play a role in a variety of physiological events such as intestinal contraction, ingestive behavior, spermatogenesis, angiogenesis, circadian rhythm, neuronal survival and hyperalgesia. PKR1 may promote cardiomyocyte survival. PKR2 is essential for the normal development of the olfactory bulb. Mutations in the gene encoding PKR2 may result in Kallmann syndrome type 3. Function: G蛋白偶联受体73A抗体Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. Subcellular Location: Cell membrane. Tissue Specificity: Expressed in the stomach, throughout the small intestine, colon, rectum, thyroid gland, pituitary gland, salivary gland, adrenal gland,G蛋白偶联受体73A抗体 testis, ovary, brain, spleen, prostate and pancreas. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 10887 Database links: Entrez Gene: 10887 Human Entrez Gene: 58182 Mouse Omim: 607122 Human SwissProt: Q8TCW9 Human SwissProt: Q9JKL1 Mouse Unigene: 683430 Human Unigene: 333226 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G蛋白偶联受体73A抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid