γ-肌聚糖/肌聚糖伽玛/γ-sarcoglycan抗体
规格：1mg/1ml
英文名： gamma Sarcoglycan
别名： 35 kDa dystrophin associated glycoprotein; 35 kDa dystrophin-associated glycoprotein; 35DAG; 35kD dystrophin associated glycoprotein; 35kDa dystrophin-associated glycoprotein; A4; DAGA4; DMDA; DMDA1;
分子量： 32kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human gamma Sa
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
细胞定位：细胞膜
γ-肌聚糖/肌聚糖伽玛/γ-sarcoglycan抗体产品介绍：background: This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008] Function: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the γ-肌聚糖/肌聚糖伽玛/γ-sarcoglycan抗体extracellular matrix. Subunit: Interacts with the syntrophin SNTA1. Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans (By similarity). Interacts with FLNC. Subcellular Location: Cell membrane; sarcolemma. Cytoplasm > cytoskeleton. Tissue Specificity: Expressed in skeletal and heart muscle. DISEASE: Defects in SGCG are the cause of limb-girdleγ-肌聚糖/肌聚糖伽玛/γ-sarcoglycan抗体 muscular dystrophy type 2C (LGMD2C) [MIM:253700]. LGMD2C is characterized by progressive muscle wasting from early childhood. Similarity: Belongs to the sarcoglycan beta/delta/gamma/zeta family. Gene ID: 6445 Database links: Entrez Gene: 6445 Human Omim: 608896 Human SwissProt: Q13326 Human Unigene: 37167 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
γ-肌聚糖/肌聚糖伽玛/γ-sarcoglycan抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 细胞骨架 跨膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid