G氨基丁酸A型受体rho3 /GABAA Rρ2/GABAc Rρ3抗体
规格：1mg/1ml
英文名： GABRR3
别名： Gamma-aminobutyric acid receptor associated protein-like 3; GBRR3_HUMAN; Gamma-aminobutyric acid receptor subunit rho-3; GABA(A) receptor subunit rho-3; GABA(C) receptor.
分子量： 52kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GABRR3
交叉反应：Human, Mouse, Rat, Cow,
细胞定位：细胞膜
G氨基丁酸A型受体rho3 /GABAA Rρ2/GABAc Rρ3抗体产品介绍：background: GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels; however, they are structurally and functionally distinct. GABAC receptors (GABAC Rr) mediate rapid inhibitory neurotransmission in retina. Three human genes, r1 (GABRR1), r2 (GABRR2) and r3 (GABRR3), encode the three polypeptides that comprise this receptor. GABRR1 and GABRR2 are located close together, in a region of chromosome 6q that contains loci for inherited disorders of the eye, but GABRR3 maps to chromosome 3q11-q13.3. The r G氨基丁酸A型受体rho3 /GABAA Rρ2/GABAc Rρ3抗体polypeptide genes, which are thought to share a common ancestor with GABA(A) receptor subunit genes, diverged at an early stage in the evolution of this gene family. The expression of GABAC Rr subunits is not restricted to the retina, but significant expression can also be detected in many other brain regions, especially in those belonging to the visual pathways. Function: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Subcellular Location: Cell junction; synapse; postsynaptic cell membrane. Cell membrane. Similarity: Belongs to the ligand-gated ionG氨基丁酸A型受体rho3 /GABAA Rρ2/GABAc Rρ3抗体 channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR3 sub-subfamily. Gene ID: 200959 Database links: Entrez Gene: 200959 Human SwissProt: A8MPY1 Human Unigene: 534578 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G氨基丁酸A型受体rho3 /GABAA Rρ2/GABAc Rρ3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid