FLJ44817蛋白抗体
规格：1mg/1ml
英文名： FLJ44817
别名： PH domain-containing family D member 1; pleckstrin homology domain containing, family D (with coiled-coil domains) member 1; PKHA1_HUMAN; pleckstrin homology domain containing, family D (with M protei
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FLJ44817
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：
FLJ44817蛋白抗体产品介绍：background: Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5% of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder α1-antitrypsin deficiency. This disorder is characterized by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14;19) translocations found in a variety of B cell malignancies. The FLJ44817 gene product has been provisionally designated FLJ44817 pending further characterization. FLJ44817蛋白抗体Function: Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. Subunit: Interacts with MPDZ and PTPN13. Subcellular Location: Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. Tissue Specificity: Highly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis,FLJ44817蛋白抗体 ovary, spinal cord, thyroid, kidney, liver, small intestine and colon. Similarity: Contains 2 PH domains. Gene ID: 400224 Database links: Entrez Gene: 400224 Human Entrez Gene: 217682 Mouse Entrez Gene: 500685 Rat SwissProt: A6NEE1 Human SwissProt: B2RPU2 Mouse SwissProt: B1WBU8 Rat Unigene: 509796 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FLJ44817蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit