组织蛋白酶K抗体
规格：1mg/1ml
英文名： Cathepsin K
别名： Cathepsin K; Procathepsin K; Cathepsin K precursor; Cathepsin O; Cathepsin O1; Cathepsin O2; Cathepsin X; CathepsinK; CTS02; CTSK; CTSK protein; CTSO; CTSO1; CTSO2; MGC23107; PKND; PYCD; Pycnodysostos
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Cathepsi
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig,
细胞定位：细胞浆
组织蛋白酶K抗体产品介绍：background: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq, Jul 2008]. Function: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular 组织蛋白酶K抗体matrix degradation. Subunit: Belongs to the peptidase C1 family. Subcellular Location: Lysosome. Tissue Specificity: Tissue specificityPredominantly expressed in osteclasts (bones). DISEASE: Defects in CTSK are the cause of pycnodysostosis (PKND) [MIM:265800]. PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. Similarity: Belongs to the peptidase C1组织蛋白酶K抗体 family. Gene ID: 1513 Database links: Entrez Gene: 1513 Human Entrez Gene: 13038 Mouse Entrez Gene: 29175 Rat Omim: 601105 Human SwissProt: P43235 Human SwissProt: P55097 Mouse SwissProt: O35186 Rat Unigene: 632466 Human Unigene: 272085 Mouse Unigene: 5598 Rat Important Note: This product as supplied is intended for 组织蛋白酶K抗体research use only, not for use in human, therapeutic or diagnostic applications. 合成与降解（Synthesis and Degradation） 组织蛋白酶K(cathepsinK)是半胱氨酸蛋白酶家族的成员,它和组织蛋白酶S、L和B有很高的同源性。 在心血管方面：组织蛋白酶K参与心血管的很多病理生理过程，在动脉硬化、血管重塑与再生。也是动脉瘤生长、破裂、主动脉辩狭窄进程中主要的胶原酶之一。 在骨与关节方面：组织蛋白酶K主要位于破骨细胞，是涉及骨质再吸收的主要酶，与骨质疏松与脱钙密切相关。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：合成与降解
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid