AAGAB蛋白抗体
规格：1mg/1ml
英文名： FLJ11506
别名： AAGAB; AAGAB_HUMAN; Alpha and gamma adaptin binding protein p34; Alpha- and gamma-adaptin-binding protein p34; LOC79719;
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FLJ11506
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：
AAGAB蛋白抗体产品介绍：background: Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and is about 3% of the human genome. Angelman and Prader-Willi syndromes are associated with loss of function or deletion of genes in the 15q11-q13 region. In the case of Angelman syndrome, this loss is due to inactivity of the maternal 15q11-q13 encoded UBE3A gene in the brain by either chromosomal deletion or mutation. In cases of Prader-Willi syndrome, there is a partial or complete deletion of this region from the paternal copy of chromosome 15. Tay-Sachs disease is a lethal disorder associated with mutations of the HEXA gene, which is encoded by chromosome 15. Marfan syndrome is associated with chromosome 15 through the FBN1 gene. The FLJ11506 gene product has been provisionally designated FLJ11506 pending further characterization. Function: May play a role in membrane traffic. Subunit: Associated with AP-1 and AP-2 complexes.AAGAB蛋白抗体 Subcellular Location: Cytoplasm, cytosol. Tissue Specificity: Widely expressed, including in skin and keratinocytes, with highest levels in adrenal gland, rectum and thymus. DISEASE: Keratoderma, palmoplantar, punctate 1A (PPKP1A) [MIM:148600]: An autosomal dominant dermatological disorder characterized by multiple hyperkeratotic, centrally indented, papules that develop in early adolescence, or later, and are irregularly distributed on the palms and soles (other palmoplantar keratoses have mostly diffuse hyperkeratinization). In mechanically irritated areas, confluent plaques can be found. Interfamilial and intrafamilial severity shows broad variation. In some cases, PPKP1 is associated with the AAGAB蛋白抗体development of early- and late-onset malignancies, including squamous cell carcinoma. Note=The disease is caused by mutations affecting the gene represented in this entry. Gene ID: 79712 Database links: Entrez Gene: 79712 Human Entrez Gene: 79719 Human Entrez Gene: 171435 Rat Omim: 614888 Human SwissProt: Q4AE62 Human SwissProt: Q6PD74 Human SwissProt: Q9R0Z7 Rat Unigene: 254642 Human Unigene: 163023 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
AAGAB蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转运蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid