FGD2蛋白抗体
规格：1mg/1ml
英文名： FGD2
别名： Fgd2; FGD2_HUMAN; FYVE; RhoGEF and PH domain-containing protein 2; ZFYVE4; Zinc finger FYVE domain-containing protein 4.
分子量： 75kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FGD2
交叉反应：Human, Mouse, Rat, Pig, Cow, Sheep,
细胞定位：细胞浆
FGD2蛋白抗体产品介绍：background: Fgd1 gene mutations result in faciogenital dysplasia (FGDY, Aarskog syndrome),an X-linked developmental disorder that adversely affects the formation of multiple skeletal structures (1). FGD1 maps to human chromosome Xp11.21 and shares a high degree of sequence identity with the FGD2 (6p21.2) and the FGD3 (9q22) proteins (1-4). FGD1 encodes a guanine nucleotide exchange factor that specifically activates the Rho GTPase Cdc42 (1,5). FGD2 is present in several diverse tissues during embryogenesis, suggesting a role in embryonic development (2). FGD3 stimulates fibroblasts to form filopodia, which are actin microspikes formed upon the stimulation of Cdc42 (1). All FGD family members contain equivalent signaling domains and a conserved structural organization, which strongly suggests that theseFGD2蛋白抗体 signaling domains form a canonical core structure for members of the FGD family of RhoGEF proteins (2). These proteins control essential signals required during embryonic development (6,7). Function: Activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphateFGD2蛋白抗体. Subcellular Location: Cytoplasm > cytoskeleton. Cytoplasm. Nucleus. Early endosome. Early endosome membrane. Cell projection > ruffle membrane. Recruitement to the endosome and ruffle membrane requires the presence of phosphoinositides. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 FYVE-type zinc finger. Contains 2 PH domains. Gene ID: 221472 Database links: Entrez Gene: 221472 Human Omim: 605091 Human SwissProt: Q7Z6J4 Human Unigene: 509664 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FGD2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid