FBXW10蛋白抗体
规格：1mg/1ml
英文名： FBXW10
别名： F-box and WD-40 domain-containing protein 10; F-box/WD repeat-containing protein 10; FBW10_HUMAN; FBXW10; Ubiquitin ligase-specificity factor.
分子量： 120kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FBXW10
交叉反应：Human, Mouse,
细胞定位：细胞浆
FBXW10蛋白抗体产品介绍：background: F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes, including the cell cycle, immune responses, signaling cascades and developmental events, through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, I?B-? and ∫-catenin, for proteasomal degradation. FBXW10 (F-box and WD repeat domain containing 10), also known as protein Ubiquitin ligase-specificity factor, is a 1,052FBXW10蛋白抗体 amino acid protein that contains one F-box domain and seven WD repeats. Existing as four alternatively spliced isoforms, FBXW10 induces degradation of CBX5 and CBX1. Function: Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation FBXW10蛋白抗体of CBX5 and CBX1. Similarity: Contains 1 F-box domain. Contains 7 WD repeats. Gene ID: 10517 Database links: Entrez Gene: 10517 Human Omim: 611679 Human SwissProt: Q5XX13 Human Unigene: 592128 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FBXW10蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid