丝氨酸/苏氨酸蛋白激酶ICK抗体
规格：1mg/1ml
英文名： phospho-ICK(Tyr159)
别名： ICK (phospho Y159); p-ICK (phospho Y159); ICK(Tyr159); 2210420N10Rik; AI848300; ECO; ICK_HUMAN; Heart serine threonine protein kinase; hICK; Intestinal cell (MAK like) kinase; Intestinal cell kinase;
分子量： 71kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Cow, Rabbit,
细胞定位：细胞核 细胞浆
丝氨酸/苏氨酸蛋白激酶ICK抗体产品介绍：background: Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. Function: May play a key role in the development of multiple organ systems and particularly in cardiac development. Subcellular Location: Nucleus. Cytoplasm, cytosol. Note=Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:12103360). Cytosolic localization was shown in rat embryonic cardiomyocytes by丝氨酸/苏氨酸蛋白激酶ICK抗体 immunostaining (PubMed:8570168). Tissue Specificity: Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines. Post-translational modifications: Autophosphorylated on serine and threonine residues. May play a role in enzyme activation. DISEASE: Endocrine-cerebroosteodysplasia (ECO) [MIM:612651]: Previously unidentified neonatal lethal recessive disorder with multiple anomalies involving the endocrine,丝氨酸/苏氨酸蛋白激酶ICK抗体 cerebral, and skeletal systems. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain. Gene ID: 22858 Database links: Entrez Gene: 22858 Human Entrez Gene: 56542 Mouse Entrez Gene: 84411 Rat Omim: 612325 Human SwissProt: Q9UPZ9 Human SwissProt: Q9JKV2 Mouse SwissProt: Q62726 Rat Unigene: 417022 Human Unigene: 288719 Mouse Unigene: 3750 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
丝氨酸/苏氨酸蛋白激酶ICK抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 细胞周期蛋白 激酶和磷酸酶 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid