磷酸化干扰素alpha/beta 受体1蛋白抗体
规格：1mg/1ml
英文名： phospho-IFNAR1(Tyr466)
别名： IFNAR1 (phospho Y466); p-IFNAR1 (phospho Y466); Alpha type antiviral protein; AVP; Beta type antiviral protein; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; IFN al
分子量： 61kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Pig, Horse,
细胞定位：
磷酸化干扰素alpha/beta 受体1蛋白抗体产品介绍：background: IFNAR1 is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Function: Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Subunit: Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type I interferon receptor. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466. Interacts with IFNAR2. Subcellular Location: Isoform 1: Membrane; Single-pass type I membrane protein.磷酸化干扰素alpha/beta 受体1蛋白抗体 Tissue Specificity: IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. Post-translational modifications: Phosphorylated on tyrosine residues by TYK2 tyrosine kinase. Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.磷酸化干扰素alpha/beta 受体1蛋白抗体 Similarity: Belongs to the type II cytokine receptor family. Contains 3 fibronectin type-III domains. Gene ID: 3454 Database links: Entrez Gene: 3454 Human Omim: 107450 Human SwissProt: P17181 Human Unigene: 529400 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化干扰素alpha/beta 受体1蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：染色质和核信号 信号转导 细胞因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid