组织蛋白酶E抗体
规格：1mg/1ml
英文名： Cathepsin E
别名： Cathepsin E; CATE; CTSE; EC 3.4.23.34; Erythrocyte membrane aspartic proteinase; CATE_HUMAN; Cathepsin E form II; Slow moving proteinase.
分子量： 38kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Cathepsi
交叉反应：Human, Mouse, Rat, Pig, Horse, Rabbit,
细胞定位：细胞浆
组织蛋白酶E抗体产品介绍：background: Cathepsin E is an intracellular aspartic protease of the pepsin family, which is structurally highly homologous to the lysosomal aspartic protease cathepsin D. Cathepsin E is less abundant than Cathepsin D and has a more limited distribution, which includes lymphoid tissues, gastrointestinal tract tissue, blood cells, microglia and activated B lymphocytes. It is not expressed in resting B lymphocytes. Cathepsin E may have a role in immune function. It is most likely involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. It may also play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain. Function: May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and 组织蛋白酶E抗体glial cell activation in the brain. Subcellular Location: Endosome. Note=The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome. Tissue Specificity: Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes. Post-translational modifications: Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and组织蛋白酶E抗体 mature enzyme contain a complex-type oligosaccharide. Two forms are produced by autocatalytic cleavage, form I begins at Ile-54, form II begins at Thr-57. Similarity: Belongs to the peptidase A1 family. Gene ID: 1510 Database links: Entrez Gene: 1510 Human Entrez Gene: 13034 Mouse Entrez Gene: 25424 Rat Omim: 116890 Human SwissProt: P14091 Human SwissProt: P70269 Mouse SwissProt: P16228 Rat Unigene: 644082 Human Unigene: 92738 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
组织蛋白酶E抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：合成与降解
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid