亚铁氧化酶抗体
规格：1mg/1ml
英文名： Hephaestin
别名： CPL; HEPH; HEPH_HUMAN; Hephaestin.
分子量： 128kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Hephaest
交叉反应：Human, Rat,
细胞定位：
亚铁氧化酶抗体产品介绍：background: Hephaestin is a single-pass type I membrane protein that belongs to the multicopper oxidase family of proteins. Hephaestin, a copper-dependant ferroxidase protein, is crucial for iron exiting intestinal enterocytes into the circulation. It mediates the movement of iron across the basolateral membrane in conjunction with ferroportin 1. This is an important link between iron and copper metabolism in mammalian systems, as copper deficiency leads to reduced hephaestin and reduced iron absorption resulting in anemia. Hephaestin can bind six copper ions per monomer and is regulated by the homeobox transcription factor CDX2. Increased levels of iron leads to an increase in 亚铁氧化酶抗体CDX2 expression and thus Hephaestin. Hephaestin is primarily detected in the intestine, but is also expressed in colon, breast, bone trabecural cells and fibroblasts. Function: May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1. Subcellular Location: 亚铁氧化酶抗体Membrane; Single-pass type I membrane protein (Potential). Tissue Specificity: Detected in breast, colon, bone trabecular cells and fibroblasts. Similarity: Belongs to the multicopper oxidase family. Contains 6 plastocyanin-like domains. Database links: UniProtKB/Swiss-Prot: Q9BQS7.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
亚铁氧化酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：信号转导 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid