HMG盒区内含蛋白1抗体
规格：1mg/1ml
英文名： HBP1
别名： FLJ16340; HBP 1; HBP1; HBP1_HUMAN; High mobility group box transcription factor 1; HMG box containing protein 1; HMG box transcription factor 1; HMG box-containing protein 1.
分子量： 58kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HBP1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：
HMG盒区内含蛋白1抗体产品介绍：background: HBP1 is a member of the HMG family of transcription factors, which are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, that mediates DNA binding. HBP-1 binds to the tumor suppressor proteins Rb and p130 and initiates cell cycle arrest.Terminal cell differentiation requires this initial cell cycle arrest followed by the coordinated expression of genes defined as tissue-specifc markers. Along with initiating the commitment to cell differentiation, the continued activity of HBP1 abrogates the expression of tissue-specific genes by associating with the MyoD proteins. In muscle cell differentiation, the MyoD family of transcription factors, which include Myf5, MyoD and myogenein, induce the expression of these cell-type specific proteins and contribute to the development ofHMG盒区内含蛋白1抗体 cell phenotypes. The progression of terminal differentiation is, therefore, dependent on both a decrease in HBP1 activity and the corresponding activation of MyoD-induced gene transcription. Function: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. Subunit: Binds the second PAH repeat of HMG盒区内含蛋白1抗体SIN3A (By similarity). Binds TCF4 and RB1. Subcellular Location: Nucleus. Similarity: Contains 1 AXH domain. Contains 1 HMG box DNA-binding domain. Database links: Entrez Gene: 26959 Human Entrez Gene: 73389 Mouse Entrez Gene: 27080 Rat SwissProt: O60381 Human SwissProt: Q8R316 Mouse SwissProt: Q62661 Rat Unigene: 162032 Human Unigene: 390461 Mouse Unigene: 458534 Mouse Unigene: 89226 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
HMG盒区内含蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 染色质和核信号 干细胞 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid