G蛋白偶联受体C5L2蛋白抗体
规格：1mg/1ml
英文名： GPCR C5L2
别名： C5a anaphylatoxin chemotactic receptor C5L2; C5ARL; C5ARL_HUMAN; C5L2; E030029A11Rik; G protein coupled receptor 77; G protein coupled receptor C5L2; G-protein coupled receptor 77; GPF77; GPR77.
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GPCR C5L
交叉反应：Human,
细胞定位：细胞膜
G蛋白偶联受体C5L2蛋白抗体产品介绍：background: Anaphylatoxin, a chemotactic and inflammatory peptide, is a receptor for C5a anaphylatoxin chemotactic receptor (C5L2), also designated G protein-coupled receptor 77. C5L2 is an integral membrane protein that belongs to the Gprotein-coupled receptor 1 family. C5L2 weakly couples to Gi-mediated signaling pathways and is widely expressed in the hippocampus, hypothalamus, pons, frontal cortex and liver. It is coexpressed with the C5a receptor (C5AR) on polymorphonuclear neutrophils and may modulate the activity of C5AR. The function of the C5a receptors, particularly that of C5L2, is still unclear. Research suggests that C5L2 may be requiredG蛋白偶联受体C5L2蛋白抗体 for the in vitro release of high mobility group box 1 protein (HMGB1). Function: Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways. Subunit: Interacts with C3 (the anaphylatoxin peptide C3a and the adipogenic hormone ASP); the interaction occurs with higher affinity for ASP, enhancing the phosphorylation and activation of GPR77, recruitment of ARRB2 to the cell surface and G蛋白偶联受体C5L2蛋白抗体endocytosis of GRP77. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Frontal cortex, hippocampus, hypothalamus, pons and liver. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 27202 Database links: Entrez Gene: 27202 Human Omim: 609949 Human SwissProt: Q9P296 Human Unigene: 534412 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G蛋白偶联受体C5L2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:10-100 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 G蛋白偶联受体 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid