1号染色体开放阅读框77抗体
规格：1mg/1ml
英文名： C1orf77
别名： Chromatin target of PRMT1 protein; Chromosome 1 open reading frame 77; CHTOP; CHTOP_HUMAN; DKFZp547E1010; FOP; Friend of PRMT1 protein; MGC131924; MGC86949; OTTHUMP00000035122; OTTHUMP00000035123; Pp7
分子量： 26kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human C1orf77
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
细胞定位：
1号染色体开放阅读框77抗体产品介绍：background: C1orf77, also known as Friend of PRMT1 protein, is a 248 amino acid protein that plays an essential role in the ligand-dependent activation of estrogen receptor target genes. C1orf77 is tightly associated with chromatin and is modified by both asymmetric and symmetric arginine methylation. Depletion of C1orf77 results in almost complete block of estradiol-induced promter occupancy by the estrogen receptor. Also, complete knockdown of C1orf77 mRNA in ***** erythroid progenitors stongly induces fetal hemoglobin, suggesting that C1orf77 is a critical modulator of γ-globin gene expression. There are two isoforms of C1orf77 that are produced as a result of alternative splicing events. The gene encoding C1orf77 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number 1号染色体开放阅读框77抗体of genes there are also a large number of diseases associated with chromosome 1. Function: Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Subunit: Interacts with PRMT1 and PRMT5. Interacts with the 5FMC complex; the interaction is methylation-dependent. Interacts with FYTTD1, SET and PRC1 complex members CBX4, RNF2 and PHC2; the interactions are methylation-independent. Interacts with ZNF148 (By similarity). Subcellular Location: Nucleus. Nucleus, nucleolus. Nucleus,1号染色体开放阅读框77抗体 nucleoplasm (By similarity). Note=Mostly associated with facultative heterochromatin (By similarity). Tissue Specificity: Expressed in an erythroid progenitor cell line derived from peripheral blood. Post-translational modifications: Asymmetrically methylated by PRMT1. Symmetrically methylated by PRMT5 (By similarity). Gene ID: 26097 Database links: Entrez Gene: 426357 Chicken Entrez Gene: 738288 Chimpanzee Entrez Gene: 616638 Cow Entrez Gene: 480140 Dog Entrez Gene: 101142690 Gorilla Entrez Gene: 26097 Human Entrez Gene: 66511 Mouse Entrez Gene: 100153064 Pig Entrez Gene: 361990 Rat Entrez Gene: 715501 Rhesus monkey Omim: 614206 Human SwissProt: Q3SYW9 Cow SwissProt: Q9Y3Y2 Human SwissProt: Q9CY57 Mouse SwissProt: Q498T2 Rat Unigene: 611057 Human Unigene: 154136 Mouse Unigene: 15859 Rat Important Note: This product as supplied is intended for research use only, not for 1号染色体开放阅读框77抗体use in human, therapeutic or diagnostic applications.
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid