FAM105B蛋白抗体
规格：1mg/1ml
英文名： FAM105B
别名： OTUL_HUMAN; Fam105b; Family with sequence similarity 105, member B; FLJ34884; OTULIN; Protein FAM105B.
分子量： 40kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FAM105B
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
细胞定位：
FAM105B蛋白抗体产品介绍：background: With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. The FAM105B gene product has been provisionally designated FAM105B pending further characterization. Function: Deubiquitinase that specifically removes linear ('Met-1'-linked) polyubiquitin chains FAM105B蛋白抗体to substrates and acts as a regulator of angiogenesis and innate immune response. Associates with the LUBAC complex via direct interaction with RNF31 and counteracts its action by cleaving linear polyubiquitin chains to substrates. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by FAM105B蛋白抗体counteracting activity of the LUBAC complex. Plays a key role in innate immune response: required to restrict linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation, probably to limit NOD2-dependent proinflammatory signaling. Subunit: Interacts with RNF31; the interaction is direct. Subcellular Location: Cytoplasm. Post-translational modifications: Ubiquitinated. Acetylated. Phosphorylated. Similarity: Belongs to the FAM105 family. Gene ID: 90268 Database links: Entrez Gene: 90268 Human Entrez Gene: 432940 Mouse SwissProt: Q96BN8 Human SwissProt: Q3UCV8 Mouse Unigene: 406335 Human Unigene: 309164 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FAM105B蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid