F-box蛋白家族FBXO3抗体
规格：1mg/1ml
英文名： FBXO3
别名： F Box G - Domain 3; F box only protein 3; F box protein 3; F box protein FBX3; F-box only protein 3; FBA; FBX3; FBX3_HUMAN; FBXO3.
分子量： 55kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FBXO3
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep,
细胞定位：细胞核
F-box蛋白家族FBXO3抗体产品介绍：background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants divergingF-box蛋白家族FBXO3抗体 at the 3' end. [provided by RefSeq, Jul 2008] Function: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergicallyF-box蛋白家族FBXO3抗体 to activate p53/TP53-dependent transactivation. Subunit: Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO3, SKP1, CUL1 and RBX1. Interacts with PML, interaction is direct and takes place either alone or within the SCF complex. Subcellular Location: Nucleus. Colocalizes with PML at the peripheries of nuclear bodies. Similarity: Contains 1 apaG domain. Contains 1 F-box domain. Gene ID: 26273 Database links: Entrez Gene: 26273 Human Entrez Gene: 57443 Mouse Entrez Gene: 690634 Rat Omim: 609089 Human SwissProt: Q9UK99 Human SwissProt: Q9DC63 Mouse SwissProt: D4ABP9 Rat Unigene: 406787 Human Unigene: 143768 Mouse Unigene: 201745 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
F-box蛋白家族FBXO3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转录调节因子 表观遗传学 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid