Exportin 4蛋白抗体
规格：1mg/1ml
英文名： Exportin 4
别名： Exp4; Exportin-4; exportin4; FLJ13046; KIAA1721; xpo4; XPO4_HUMAN.
分子量： 130kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Exportin
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse,
细胞定位：细胞核 细胞浆
Exportin 4蛋白抗体产品介绍：background: XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009] Function: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex Exportin 4蛋白抗体(NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is Exportin 4蛋白抗体thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Subcellular Location: Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Similarity: Belongs to the exportin family. Gene ID: 64328 Database links: Entrez Gene: 64328 Human Entrez Gene: 57258 Mouse Entrez Gene: 290280 Rat Omim: 611449 Human SwissProt: Q9C0E2 Human SwissProt: Q9ESJ0 Mouse SwissProt: D3ZQI6 Rat Unigene: 725169 Human Unigene: 202747 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Exportin 4蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid