长链脂肪酸延长酶ELOVL4抗体
规格：1mg/1ml
英文名： ELOVL4
别名： 3-keto acyl-CoA synthase ELOVL4; ADMD; Cancer/testis antigen 118; CT118; Elongation of very long chain fatty acids (FEN1/Elo2 SUR4/Elo3 yeast) like 4; elongation of very long chain fatty acids (FEN1/E
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ELOVL4
交叉反应：Human, Mouse, Rat, Horse, Rabbit,
细胞定位：
长链脂肪酸延长酶ELOVL4抗体产品介绍：background: This gene encodes a membrane-bound protein which is a member of the ELO family, proteins which participate in the biosynthesis of fatty acids. Consistent with the expression of the encoded protein in photoreceptor cells of the retina, mutations and small deletions in this gene are associated with Stargardt-like macular dystrophy (STGD3) and autosomal dominant Stargardt-like macular dystrophy (ADMD), also referred to as autosomal dominant atrophic macular degeneration. [provided by RefSeq, Jul 2008] Function: Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Elongates C24:0 and C26:0 acyl-CoAs. Seems to represent a photoreceptor-specific component of the fatty acid elongation system residing on the endoplasmic reticulum. 长链脂肪酸延长酶ELOVL4抗体May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps Subunit: Oligomer. Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Expressed in the retina and at much lower level in the brain. Ubiquitous, highest expression in thymus, followed by testis, small intestine, ovary, and prostate. Little or no espression in heart, lung, liver, or leukocates. DISEASE: Defects in ELOVL4 are the cause of Stargardt disease type长链脂肪酸延长酶ELOVL4抗体 3 (STGD3) [MIM:600110]. STGD is one of the most frequent causes of macular degeneration in childhood. It is characterized by macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral retina, and subretinal deposition of lipofuscin-like material. STGD3 inheritance is autosomal dominant. Similarity: Belongs to the ELO family. Gene ID: 6785 Database links: Entrez Gene: 6785 Human Entrez Gene: 83603 Mouse Omim: 605512 Human SwissProt: Q9GZR5 Human SwissProt: Q9EQC4 Mouse SwissProt: Q920L7 Rat Unigene: 101915 Human Unigene: 83949 Mouse Unigene: 7567 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
长链脂肪酸延长酶ELOVL4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 转录调节因子 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid