ECSIT蛋白抗体
规格：1mg/1ml
英文名： ECSIT
别名： Ecsit; ECSIT homolog; ECSIT protein; ECSIT_HUMAN; Evolutionarily conserved signaling intermediate in Toll pathway; Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Evolu
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ECSIT
交叉反应：Human, Mouse, Rat, Dog, Cow, Sheep,
细胞定位：细胞核 细胞浆
ECSIT蛋白抗体产品介绍：background: ECSIT is a 431 amino acid ubiquitously expressed protein that plays an important role as an adaptor protein in the cytosolic signal transduction cascade events triggered by Toll receptor activation. Within the Toll pathway, ECSIT regulates MEKK1 processing for activation of NFκB, a major event leading to initiation of the innate immune response. In the mitochondria, ECSIT interacts with NDUFAF1 and assists in the formation of NADH:ubiquinone oxidoreductase (complex I), an extremely complicated multiprotein complex located in the inner mitochondrial membrane that functions in the transport of electrons from NADH to ubiquinone. Knockdown of ECSIT results in severely impaired complex I assembly and disturbed mitochondrial function. There are two isoforms of ECSIT that are produced as a result ofECSIT蛋白抗体 alternative splicing events Function: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase. Subunit: Interacts with MAP3K1, ECSIT蛋白抗体SMAD4 and TRAF6. Interacts with SMAD1 only after BMP4-treatment (By similarity). Part of the mitochondrial complex I assembly (MCIA) complex. The complex comprises at least TMEM126B, NDUFAF1, ECSIT, and ACAD9 (By similarity). Interacts with NDUFAF1. Subcellular Location: Cytoplasm. Nucleus. Mitochondrion. Similarity: Belongs to the ECSIT family. Gene ID: 51295 Database links: Entrez Gene: 51295 Human Entrez Gene: 26940 Mouse Entrez Gene: 300447 Rat Omim: 608388 Human SwissProt: Q9BQ95 Human SwissProt: Q9QZH6 Mouse SwissProt: Q5XIC2 Rat Unigene: 515146 Human Unigene: 425568 Mouse Unigene: 8455 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ECSIT蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid