DOC2A蛋白抗体
规格：1mg/1ml
英文名： DOC2A
别名： Doc2; Doc2-alpha; Doc2a; DOC2A_HUMAN; Double C2 like domains, alpha; Double C2-like domain-containing protein alpha.
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DOC2A
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：
DOC2A蛋白抗体产品介绍：background: There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] Function: DOC2A蛋白抗体Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. SubcellularDOC2A蛋白抗体 Location: Lysosome. Cytoplasmic vesicle; secretory vesicle; synaptic vesicle membrane. Cell junction; synapse; synaptosome. Colocalizes to synaptic vesicles. Tissue Specificity: Predominantly expressed in brain. Also expressed in testis. Similarity: Contains 2 C2 domains. Gene ID: 8448 Database links: Entrez Gene: 8448 Human Entrez Gene: 13446 Mouse Entrez Gene: 65031 Rat Omim: 604567 Human SwissProt: Q14183 Human SwissProt: Q7TNF0 Mouse SwissProt: P70611 Rat Unigene: 355281 Human Unigene: 220257 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DOC2A蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid