轴丝动力蛋白12抗体
规格：1mg/1ml
英文名： DNAH12
别名： DYH12_HUMAN; Dynein heavy chain 12, axonemal; Axonemal beta dynein heavy chain 12; Axonemal dynein heavy chain 12-like protein; Axonemal dynein heavy chain 12 like protein; Axonemal dynein heavy chain
分子量： 357kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DNAH12
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：细胞浆
轴丝动力蛋白12抗体产品介绍：background: Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; complexes that transport cellular cargo toward the central region of the cell. Axonemal dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. DNAH12 is a 3,092 amino acid protein of cilium 轴丝动力蛋白12抗体axoneme that exists as three alternatively spliced isoforms. A member of the dynein heavy chain family, DNAH12L is involved in sperm flagellar assembly and is encoded by a gene located on human chromosome 3. Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on 轴丝动力蛋白12抗体release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly Subunit: Consists of at least two heavy chains and a number of intermediate and light chains. Subcellular Location: Cytoplasm, cytoskeleton, cilium axoneme. Similarity: Belongs to the dynein heavy chain family. Gene ID: 201625 Database links: Entrez Gene: 201625 Human SwissProt: Q6ZR08 Human Unigene: 201378 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
轴丝动力蛋白12抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid