轴丝动力蛋白1抗体
规格：1mg/1ml
英文名： DNAH1
别名： axonemal; Axonemal beta dynein heavy chain 1; Ciliary dynein heavy chain 1; DNAH1; DNAHC1; DYH1_HUMAN; Dynein heavy chain 1; hDHC7; Heat shock regulated protein 1; Ciliary dynein heavy chain 1; HL 11;
分子量： 494kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DNAH1
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit,
细胞定位：细胞浆
轴丝动力蛋白1抗体产品介绍：background: Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Axonemal Dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. DNAH1 (dynein heavy chain 1, axonemal), also known as heat shock regulated protein 1 or ciliary dynein heavy chain 1,轴丝动力蛋白1抗体 is a 4,330 amino acid protein consisting of at least two heavy chains and several intermediate and light chains. Mutations in the gene encoding DNAH1 may be a cause of primary ciliary dyskinesia, also known as Kartagener Syndrome, which is characterized by chronic recurrent respiratory infections due to defective cilia action in the respiratory tract. There are three isoforms of DNAH1 that exist as a result of alternative splicing events. Function: Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity;轴丝动力蛋白1抗体 the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. Subcellular Location: Cytoplasm > cytoskeleton > cilium axoneme. Tissue Specificity: Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain. Similarity: Belongs to the dynein heavy chain family. Gene ID: 25981 Database links: Entrez Gene: 25981 Human Omim: 603332 Human SwissProt: Q9P2D7 Human Unigene: 655469 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
轴丝动力蛋白1抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid