11号染色体开放阅读框5抗体
规格：1mg/1ml
英文名： CWC15
别名： CWC15; AD-002; C11orf5; CWC15_HUMAN; HSPC148; Spliceosome-associated protein CWC15 homolog.
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CWC15/C1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse,
细胞定位：细胞核
11号染色体开放阅读框5抗体产品介绍：background: CWC15 is a 229 amino acid protein involved in pre-mRNA splicing. The gene encoding CWC15 maps to human chromosome 11q21. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the11号染色体开放阅读框5抗体 disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and β thalassemia are caused by HBB gene mutations. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects11号染色体开放阅读框5抗体 in chromosome 11. Function: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Belongs to the CWC15 family. Subcellular Location: Nucleus Similarity: Belongs to the CWC15 family. Database links: SwissProt: Q2KJD3 Cow SwissProt: Q9P013 Human SwissProt: Q9JHS9 Mouse SwissProt: Q5BJP2 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
11号染色体开放阅读框5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid