环磷酸腺苷调节元件相关蛋白1抗体
规格：1mg/1ml
英文名： CROP
别名： cAMP regulatory element-associated protein 1; Cisplatin resistance-associated overexpressed protein; Cisplatin resistance-associated-overexpressed protein; CRE-associated protein 1; CREAP-1; CREAP1; C
分子量： 51kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CROP
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Sheep,
细胞定位：细胞核
环磷酸腺苷调节元件相关蛋白1抗体产品介绍：background: This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009] Function: Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing. Subcellular Location: Nucleus环磷酸腺苷调节元件相关蛋白1抗体 speckle. The subnuclear localization is affected by cisplatin. Tissue Specificity: Widely expressed. Highest levels in heart, brain, pancreas, thymus, ovary, small intestine and peripheral blood leukocytes, as well as cerebellum, putamen and pituitary gland. Lowest levels in lung, liver and kidney. Also expressed in fetal tissues, including brain, heart, kidney, thymus and lung. Post-translational modifications: Phosphorylated in vitro by SRPK1, SRPK2 and CLK1. Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the Luc7 family. Gene ID: 51747环磷酸腺苷调节元件相关蛋白1抗体 Database links: Entrez Gene: 51747 Human Entrez Gene: 67684 Mouse Entrez Gene: 360602 Rat Omim: 609434 Human SwissProt: O95232 Human SwissProt: Q5SUF2 Mouse Unigene: 130293 Human Unigene: 30927 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环磷酸腺苷调节元件相关蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid