ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体
规格：1mg/1ml
英文名： GEP100/IQSEC1
别名： ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; ARF GEP100; ARFGEP100; BRAG2; Brefeldin A resistant ARF GEF2; Brefeldi
分子量： 108kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GEP100
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep,
细胞定位：细胞核 细胞浆
ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体产品介绍：background: The ADP-ribosylation factor (ARF) protein family are structurally and functionally conserved members of the Ras superfamily of regulatory GTP-binding proteins. ARFs influence vesicle trafficking and signal transduction in eukaryotic cells. ARF6 plays a role in protein trafficking near the plasma membrane, including receptor recycling, cell adhesion and cell migration. ARF6 colocalizes with the ARF guanine nucleotide-exchange protein (GEP) BRAG2, also designated GEP100. BRAG2 is ubiquitously expressed as two isoforms, BRAG2a and BRAG2b, which can cycle between the cytoplasm and the nucleus. BRAG2, via its interaction ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体with ARF6, is involved in the regulation of cell adhesion by controlling Integrin ∫1 endocytosis and E-cadherin redistribution. BRAG2 has also been shown to bind directly to Tyr1068/1086-phosphorylated EGFR to activate ARF6, which induces tumor invasion in MCF7 cells. Therefore, BRAG2 may contribute to the metastasis and malignancy of some breast cancer cells. Function: In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体internalisation of beta-1 integrin. Subcellular Location: Cytoplasm. Nucleus. At steady state, may be preferentially cytosolic. Tissue Specificity: Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis. Similarity: Belongs to the BRAG family. Contains 1 IQ domain. Contains 1 PH domain. Contains 1 SEC7 domain. Gene ID: 9922 Database links: Entrez Gene: 9922 Human Omim: 610166 Human SwissProt: Q6DN90 Human Unigene: 475506 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 转录调节因子 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid