CENTB2蛋白抗体
规格：1mg/1ml
英文名： Centaurin beta 2
别名： ACAP 2; ACAP2; ACAP2_HUMAN; ANK repeat and PH domain-containing protein 2; Ankyrin repeat; Arf GAP with coiled coil ANK repeat and PH domains 2; ARF GAP with coiled coil; Arf-GAP with coiled-coil; CEN
分子量： 88kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Centauri
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆
CENTB2蛋白抗体产品介绍：background: The ADP-ribosylation factor (ARF) family of small GTP-binding proteins are involved in vesicular transport regulation and in controlling cytoskeletal organization and cell adhesion. These proteins mainly regulate membrane traffic. ACAP2 is a member of the centaurin GTPase-activating protein (GAP) family, which comprises a subset of ARF regulatory molecules that transduce PI 3-kinase activation into coordinated control of ARF-dependent pathways. ACAP1 and ACAP2 are both widely expressed in peripheral, tubular membranes and usually interact with each other in various tissues. GAP activity of both ACAP1 and ACAP2 is dependent upon phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2]. ACAP2 associates with ARF1 and ARF6. Overexpression of ACAP2 blocks the formation of ARF6-dependent protrusions.CENTB2蛋白抗体 K1L is a protein required for growth of the Vaccinia Virus that interacts with the ankyrin repeats of ACAP2. Function: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). Tissue Specificity: Widely expressed. Highest level in lung. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 3 ANK repeats. Contains 1 Arf-GAP domain. Contains 1 BAR domain. CENTB2蛋白抗体Contains 1 PH domain. Gene ID: 23527 Database links: Entrez Gene: 23527 Human Entrez Gene: 78618 Mouse Entrez Gene: 619382 Rat GenBank: NM_030138 Mouse GenBank: NM_001034006 Rat Omim: 607766 Human SwissProt: Q15057 Human SwissProt: Q3UHL4 Mouse SwissProt: Q6ZQK5 Mouse SwissProt: Q5FVC7 Rat Unigene: 478746 Human Unigene: 593373 Human Unigene: 274646 Mouse Unigene: 208307 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CENTB2蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid