紧密连接蛋白18抗体
规格：1mg/1ml
英文名： Claudin 18
别名： Claudin 18; Claudin-18; CLD18_HUMAN; CLDN18; SFTA5; SFTPJ.
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Claudin
交叉反应：Human, Rat, Pig, Rabbit,
细胞定位：细胞膜
紧密连接蛋白18抗体产品介绍：background: The Claudin superfamily consists of many structurally related proteins in humans (1). These proteins are important structural and functional components of tight junctions in paracellular transport (1,2). Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues (1). Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule (3). Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands (4). Emerging evidence suggests that the Claudin family of proteins regulates transport through tight junctions via differential 紧密连接蛋白18抗体discrimination for solute size and charge (5).Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions (6). Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Subcellular Location: Cell junction > tight junction. Cell membrane紧密连接蛋白18抗体. Tissue Specificity: Concentrated at the cell-cell borders of epithelial cells. Similarity: Belongs to the claudin family. Gene ID: 51208 Database links: Entrez Gene: 51208 Human Entrez Gene: 56492 Mouse Entrez Gene: 315953 Rat Omim: 609210 Human SwissProt: P56856 Human SwissProt: P56857 Mouse SwissProt: D3ZLY1 Rat Unigene: 655324 Human Unigene: 386784 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
紧密连接蛋白18抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 转运蛋白 细胞粘附分子 内皮细胞 跨膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid