平滑肌蛋白抗体
规格：1mg/1ml
英文名： Smoothelin
别名： FLJ35168; FLJ35365; FLJ35620; FLJ38597; Smoothelin; SMSMO; Smtn; SMTN_HUMAN.
分子量： 100kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Smoothel
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Orangutan
细胞定位：细胞浆
平滑肌蛋白抗体产品介绍：background: The cytoskeletal protein smoothelin is highly conserved among vertebrates and is expressed exclusively by contractile smooth muscle cells where it localizes to the filament network. Smoothelin associates with actin stress fibers but does not interact with desmin. At least two isoforms of smoothelin are produced by alternative splicing. The short isoform lacks amino acids 1–544 at the amino-terminus of the long isoform. The short isoform is expressed in visceral muscle tissue, including intestine and stomach, but not in brain, while the long isoform is expressed in all vascularized organs. In the vascular system, smoothelin expression is limited to large veins and arteries capable平滑肌蛋白抗体 of pulsatile contraction. As a marker for the highly differentiated contractile smooth muscle cell, smoothelin expression is useful for studying vascular malformation and injury. The gene encoding human smoothelin maps to chromosome 22q12.2. Function: Structural protein of the cytoskeleton. Subcellular Location: Cytoplasm > cytoskeleton. Exhibits a filamentous organization. Tissue Specificity: Smooth muscle; contractile or vascular 平滑肌蛋白抗体(for the long form). Similarity: Belongs to the smoothelin family. Contains 1 CH (calponin-homology) domain. Gene ID: 6525 Database links: Entrez Gene: 6525 Human Entrez Gene: 29856 Mouse Entrez Gene: 289734 Rat Omim: 602127 Human SwissProt: P53814 Human SwissProt: Q921U8 Mouse Unigene: 149098 Human Unigene: 188516 Mouse Unigene: 40766 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
平滑肌蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞类型标志物 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid