原钙粘附蛋白β6抗体
规格：1mg/1ml
英文名： PCDHB6
别名： PCDH beta6; ?PCDH beta 6; PCDHB 6; Protocadherin beta 6; PCDB6_HUMAN.
分子量： 84kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PCDHB6
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
细胞定位：细胞膜
原钙粘附蛋白β6抗体产品介绍：background: Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDHB6 (Protocadherin beta-6) is a 794 amino acid single pass transmembrane protein that is one of 16 proteins in the protocadherin beta cluster. Unlike the alpha and gamma gene clusters whose genes are spliced to downstream constant region exons during transcription, members of the beta cluster (such as PCDHB6) do not use constant-region exons to produce mRNAs. As a result, each protocadherin beta gene encodes the transmembrane, extracellular and short cytoplasmic domains of 原钙粘附蛋白β6抗体the protein. PCDHB6 is likely a calcium-dependent cell adhesion protein that is involved in the maintenance of neural connections in the brain. Unlike most protocadherin-beta proteins, PCDHB6 has not one but two PXXP motifs within its cytoplasmic domain, suggesting a role in signal transduction cascade events. Function: PCDHB6 (Protocadherin beta 6) is a member of the protocadherin family, a subgroup of the cadherin 原钙粘附蛋白β6抗体superfamily. Protocadherins are neural cadherin-like cell adhesion proteins that are integral membrane proteins. The specific function of PCDHB6 is unknown but it is thought to be involved in the establishment and maintenance of specific neuronal connections in the brain. PCDHB6 is a member of the beta cluster of protocadherin genes on 5q31. Subcellular Location: Cell membrane. Single-pass type I membrane protein. Similarity: Contains 6 cadherin domains. Gene ID: 56130 Database links: Entrez Gene: 56130 Human Omim: 606332 Human SwissProt: Q9Y5E3 Human Unigene: 283085 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
原钙粘附蛋白β6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid