P38相互作用蛋白抗体
规格：1mg/1ml
英文名： FAM48A
别名： SP20H_HUMAN; Transcription factor SPT20 homolog; p38-interacting protein; p38IP.
分子量： 86kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FAM48A
交叉反应：Human, Mouse, Rat, Cow,
细胞定位：细胞核
P38相互作用蛋白抗体产品介绍：background: FAM48A is a 779 amino acid protein that interacts with p38 MAP kinase. Specifically, FAM48A and p38 are required for downregulation of E-cadherin during gastrulation. In ***** tissues, FAM48A is highly expressed in testis and moderately expressed in brain and pituitary gland. It is also expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression of FAM48A has been shown to be downregulated in malignant prostate tissues. The gene encoding FAM48A maps to human chromosome 13, which houses over 400 genes and comprises approximately 4% of the human genome. Key tumor suppressor genes on chromosome 13 include theP38相互作用蛋白抗体 breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. Function: Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by Fgf signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy. Subcellular Location: Nucleus. Tissue Specificity: HighlP38相互作用蛋白抗体y expressed in testis, moderately in brain and pituitary gland. Expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression is down-regulated in malignant prostate tissues. Similarity: Belongs to the FAM48 family. Gene ID: 55578 Database links: Entrez Gene: 55578 Human Entrez Gene: 534126 Cow Entrez Gene: 56790 Mouse Entrez Gene: 361946 Rat Omim: 613417 Human SwissProt: Q8NEM7 Human SwissProt: Q7TT00 Mouse SwissProt: Q66HC7 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
P38相互作用蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid