尿路上皮特异蛋白3抗体
规格：1mg/1ml
英文名： UPK3A
别名： Uroplakin III; MGC119178; OTTHUMP00000028951; UP III; UP3A; UPIII; UPIIIA; UPK 3; UPK 3A; UPK3; UPK3A; UPK3A_HUMAN; Uroplakin 3A; Uroplakin III; Uroplakin-3a; Uroplakin3A; UroplakinIII.
分子量： 29kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human UPK3A
交叉反应：Human, Mouse, Rat, Pig, Cow, Sheep,
细胞定位：细胞膜
尿路上皮特异蛋白3抗体产品介绍：background: The asymmetric unit membrane (AUM) forms numerous plaques, which cover the apical surface of the urothelium. These plaques are thought to strengthen the urothelium and reduce the risk of rupturing during ladder distention. They are composed of four major integral membrane proteins called uroplakins (UP). The uroplakin family comprises UPIa, UPIb, UPII, and UPIII. Family members are conserved among several species, including human, mouse, rat, rabbit, dog, pig and sheep. UPIa and UPIb form tightly packed structures with UPII and UPIII, respectively. This pairing is required for normal urothelial plaque formation and is regulated by proteolytic 尿路上皮特异蛋白3抗体processing of the uroplakin proteins. Uroplakins are expressed in normal urothelium and are used as specific markers of urothelial differentiation. They are also expressed in a majority of transitional cell carcinomas of the bladder (TCCs), which make the uroplakins a useful marker for detecting bladder cancer metastasis and for staging and monitoring chemotherapeutic response. Function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence. Subcellular Location: Endoplasmic reticulum membrane. Heterodimer formation with UPK1B is a prerequisite to exit out 尿路上皮特异蛋白3抗体of the endoplasmic reticulum (ER). Tissue Specificity: Expressed in ureter. DISEASE: Defects in UPK3A are a cause of renal adysplasia (RADYS) [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy. Similarity: Belongs to the uroplakin-3 family. Gene ID: 7380 Database links: Entrez Gene: 7380 Human Omim: 611559 Human SwissProt: O75631 Human SwissProt: Q32N05 Human Unigene: 632787 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
尿路上皮特异蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid