钠离子通道相关蛋白1抗体
规格：1mg/1ml
英文名： SCLT1
别名： CAP-1A; CAP1A; FLJ30655; hCAP-1A; SAP1; SCLT1; SCLT1_HUMAN; Sodium channel and clathrin linker 1; Sodium channel-associated protein 1.
分子量： 81kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SCLT1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆
钠离子通道相关蛋白1抗体产品介绍：background: SCLT1 (sodium channel and clathrin linker 1), also known as CAP1A or hCAP-1A, is a 688 amino acid cytoplasmic protein that acts as a linker between the voltage-gated sodium channel, Na+ CP type X? and clathrin. SCLT1 is abundantly expressed in DRG (dorsal root ganglia) neurons and colocalizes with Na+ CP type X? SCLT1 regulates Na+ CP type X?channel activity by promoting channel internalization. SCLT1 exists as four alternatively spliced isoforms and is encoded by a gene located on human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of钠离子通道相关蛋白1抗体 all human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. Function: Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization. Subunit: Interacts with SCN10A and clathrin. 钠离子通道相关蛋白1抗体Identified in a complex containing SCN10A, clathrin and SCLT1 (By similarity). Subcellular Location: Cytoplasm. Cell periphery. Database links: Entrez Gene: 132320 Human Omim: 611399 Human SwissProt: Q96NL6 Human Unigene: 654690 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钠离子通道相关蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 通道蛋白
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid