信号转导接头蛋白2抗体
规格：1mg/1ml
英文名： STAP2
别名： BKS; Breast tumor kinase substrate; BRK substrate; Signal transducing adaptor protein 2; Signal-transducing adaptor protein 2; Ssignal transducing adaptor family member 2; STAP 2; STAP-2; STAP2; STAP2
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human STAP2
交叉反应：Human,
细胞定位：细胞浆
信号转导接头蛋白2抗体产品介绍：background: Protein kinases comprise a large group of encoded factors that regulate cellular processes by catalyzing the transfer of a phosphate group to a hydroxyl acceptor in serine, threonine or tyrosine residues (1,2). Kinases are capable of influencing the oncogenic potential of cell sytems at the level of oncoprotein or tumor suppressor protein phosphorylation states (1,2). STAP-2 is a protein that contains a pleckstrin homology (PH) domain and an SH2 domain, and associates with BRK (3). BRK (breast tumor kinase,信号转导接头蛋白2抗体 Sik) is a 451 amino acid, nonreceptor protein-tyrosine kinase that is overexpressed in breast tumors and metastatic melanoma cell lines (4). Similar to the Src family of intracellular kinses, BRK is comprised of an SH3 domain, an SH2 domain, and a catalytic domain (5). STAP-2 is susceptiple to tyrosine phosphorylation and may be invovled in tyrosine kinase-mediated signaling cascades, whose aberrant function may lead to metastis (3). Function: Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may信号转导接头蛋白2抗体 modulate STAT3 activity. Subunit: Interacts with PTK6 and CSF1R. Subcellular Location: Cytoplasm. Tissue Specificity: Widely expressed. Post-translational modifications: Phosphorylated on tyrosine. Tyr-250 may be important for interaction with kinases. Tyr-22 and Tyr-322 appears to be phosphorylated by SRC. Similarity: Contains 1 PH domain. Contains 1 SH2 domain. Database links: Entrez Gene: 55620 Human Omim: 607881 Human SwissProt: Q9UGK3 Human Unigene: 194385 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
信号转导接头蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid