SLAP2抗体
规格：1mg/1ml
英文名： SLAP2
别名： A930009E21Rik; AI430952; C20orf156; FLJ21992; MARS; MGC49845; Modulator of antigen receptor signaling; RGD1562071; SLA 2; SLA2; SLAP 2; SLAP-2; SLAP2; SLAP2_HUMAN; Src like adapter protein 2; Src like
分子量： 29kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SLAP2
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
细胞定位：细胞膜
SLAP2抗体产品介绍：background: SLA2 is a 261 amino acid protein that exists as four alternatively spliced isoforms which localize to either the cytoplasm or to the cell membrane and contain one SH2 domain and one SH3 domain. Expressed predominately in tissues of the immune system, including thymus, spleen and lymph nodes, SLA2 functions as an adaptor protein that negatively regulates T-cell receptor (TCR) signaling and may inhibit T-cell activation. SLA2 interacts with Zap-70 and is subject to post-translational phosphorylation. The gene encoding SLA2 maps to human chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophySLAP2抗体, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Function: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Subunit: Interacts (via SH2 domain) with ZAP70 (phosphorylated) and CD3Z (phosphorylated). Interacts (via SH2 domain) with CSF1R (phosphorylated) (By similarity). Interacts (via its C-terminal domain) with CBL (phosphorylated)SLAP2抗体. Subcellular Location: Cytoplasm. Tissue Specificity: Predominantly expressed in immune system, with highest levels in peripheral blood leukocytes. Expressed in spleen, thymus and lymph nodes. Expressed in T-cells as well as in monocytes, and at low level in B-cells. Also detected in placenta, prostate, skin, retina and colon. Post-translational modifications: Phosphorylated by CSF1R (By similarity). Similarity: Contains 1 SH2 domain. Contains 1 SH3 domain. Database links: Entrez Gene: 84174 Human Omim: 606577 Human SwissProt: Q9H6Q3 Human Unigene: 713578 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
SLAP2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞膜受体 **细胞 t-**细胞 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid