**细胞特异性接头蛋白抗体
规格：1mg/1ml
英文名： LNK
别名： IDDM20; Lymphocyte adapter protein; Lymphocyte specific adapter protein; Lymphocyte specific adapter protein Lnk; Lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; SH2B adaptor protein
分子量： 63kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human LNK
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Sheep, Monkey,
细胞定位：细胞膜
**细胞特异性接头蛋白抗体产品介绍：background: APS (adapter molecule containing PH and SH2 domains), SH2-B and Lnk compose a family of adapter proteins, which contain a pleckstrin homology (PH) domain, an SH2 domain and a tyrosine phosphorylation site. Stimulation of B cell receptor (BCR) or T cell receptor (TCR) results in the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of BCR, TCR and several substrates. APS, SH2-B and Lnk may bind to the ITAM domain of BCR and TCR. Lnk is tyrosine phosphorylated in response to TCR stimulation and APS has been shown to be tyrosine phosphorylated in response to BCR stimulation. Function: Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. Tissue Specificity: Preferentially expressed by lymphoid cell lines**细胞特异性接头蛋白抗体. Post-translational modifications: Tyrosine phosphorylated by LCK. DISEASE: Genetic variations in SH2B3 are associated with susceptibility to celiac disease type 13 (CELIAC13)[MIM:612011]; also known as susceptibility to gluten-sensitive enteropathy type 13. Celiac disease is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins**细胞特异性接头蛋白抗体. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive. Genetic variations in SH2B3 are associated with susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100]; also known as diabetes mellitus type 1. IDDM normally starts in childhood or adolescence and is caused by the body's own immune system which destroys the insulin-producing beta cells in the pancreas. Classical features are polydipsia, polyphagia and polyuria, due to hyperglycemia-induced osmotic diuresis. Similarity: Belongs to the SH2B adapter family. Contains 1 PH domain. Contains 1 SH2 domain. Database links: Entrez Gene: 10019 Human Entrez Gene: 16923 Mouse Entrez Gene: 58838 Rat Omim: 605093 Human SwissProt: Q9UQQ2 Human SwissProt: O09039 Mouse SwissProt: P50745 Rat Unigene: 506784 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
**细胞特异性接头蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 **细胞 t-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid