生长因子受体结合蛋白7抗体
规格：1mg/1ml
英文名： GRB7
别名： B47; Epidermal growth factor receptor GRB 7; Epidermal growth factor receptor GRB-7; GRB7 adapter protein; GRB7; GRB7_HUMAN; Growth factor receptor bound protein 7; Growth factor receptor-bound protei
分子量： 60kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GRB7
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
生长因子受体结合蛋白7抗体产品介绍：background: Many growth factors function by binding receptors with intrinsic tyrosine kinase activity (1,2). Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and the phosphotyrosine-containing receptor sequences (3,4). GRB7生长因子受体结合蛋白7抗体, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP and a proline-rich N-terminus (5,6). GRB7 maps to the region on mouse chromosome 11 containing the Neu gene (6). This region of mouse chromosome 11 is syntenic to an area of human chromosome 17q that is frequently amplified in breast cancer (6,7). Moreover, GRB7 is amplified and over-expressed in breast cancer and is found in a complex with Neu gp185 (6). Function: Interacts with the cytoplasmic domain of the epidermal growth factor receptor 生长因子受体结合蛋白7抗体which is then inhibited. The interaction is mediated by the SH2 domain. Also binds to ERBB2. Post-translational modifications: Phosphorylated on tyrosine residues. Similarity: Belongs to the GRB7/10/14 family. Contains 1 PH domain. Contains 1 Ras-associating domain. Contains 1 SH2 domain. Gene ID: 2886 Database links: Entrez Gene: 2886 Human Entrez Gene: 14786 Mouse Entrez Gene: 84427 Rat Omim: 601522 Human SwissProt: Q14451 Human SwissProt: Q03160 Mouse SwissProt: Q9QZC5 Rat Unigene: 86859 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
生长因子受体结合蛋白7抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 激酶和磷酸酶 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid