氯离子通道蛋白2抗体
规格：1mg/1ml
英文名： CLIC2
别名： Chloride intracellular channel 2; Chloride intracellular channel protein 2; CLIC 2b; CLIC2; CLIC2_HUMAN; CLIC2b; MRXS32; OTTHUMP00000196471; XAP 121; XAP121.
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CLIC2
交叉反应：Human, Rat, Chicken, Rabbit,
细胞定位：细胞膜
氯离子通道蛋白2抗体产品介绍：background: Chloride channels (CLCs) regulate cellular traffic of chloride ions, a critical component of all living cells. CLCs are involved in membrane potential stabilization, signal transduction, cell volume regulation and organic solute transport. The putative 247 amino acid protein chloride intracellular channel 2 (CLIC2), also designated XAP121, shares 60% identity with the CLIC1 protein and demonstrates expression in only fetal liver and ***** skeletal muscle tissues. The CLIC2 gene maps to chromosome Xq28 and contains 6氯离子通道蛋白2抗体 exons. Because a direct association exists between a number of human chloride channel genes and a range of hereditary diseases, CLIC2 is a potential candidate for one of the many diseases linked to Xq28. The hereditary form of incontinentia pigmenti (IP2), for example, is a rare disorder characterized by abnormalities of the tissues and organs derived from the ectoderm and neuroectoderm that has been linked to Xq28 Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. Subcellular Location: Cytoplasm.氯离子通道蛋白2抗体 Membrane. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Tissue Specificity: Detected in ***** brain, heart, liver, lung, spleen, stomach and testis. Expressed in fetal liver and ***** skeletal muscle. Similarity: Belongs to the chloride channel CLIC family. Contains 1 GST C-terminal domain. Gene ID: 1193 Database links: Entrez Gene: 1193 Human Entrez Gene: 422178 Chicken Entrez Gene: 294141 Rat Omim: 300138 Human SwissProt: O15247 Human SwissProt: Q5M883 Rat Unigene: 655445 Human Unigene: 103254 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
氯离子通道蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid