C型凝集素结构域家族12成员A抗体
规格：1mg/1ml
英文名： CLEC12A
别名： C-type lectin domain family 12 member A; C-type lectin-like molecule 1; CL12A_HUMAN; CLEC12A; CLL-1; DCAL-2; Dendritic cell-associated lectin 2; MICL; Myeloid inhibitory C-type lectin-like receptor.
分子量： 31kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CLEC12A
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
C型凝集素结构域家族12成员A抗体产品介绍：background: The C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily consists of a variety of proteins that share a common protein fold and have diverse functions, including cell-cell signaling, cell adhesion, glycoprotein turnover and immune responses. CLEC-12A (C-type lectin domain family 12, member A), also known as CLL1, MICL, CLL-1 or DCAL-2, is a 275 amino acid single-pass type II membrane protein that contains one C-type lectin domain and belongs to the CTL/CTLD superfamily. Existing as multiple alternatively spliced isoforms that are expressed in neutrophils, eosinophils, monocytes and dendritic cells, CLEC-12A functions as a cell surfaceC型凝集素结构域家族12成员A抗体 receptor that acts as a negative regulator of granulocyte and monocyte function and, via this activity, modulates signaling cascades. CLEC-12A is highly subject to post-translational glycosylation at its N-terminus and may also exist as a homodimer. Function: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. Subcellular Location: Cell membrane. Ligand binding leads to internalization. Tissue Specificity: Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils,C型凝集素结构域家族12成员A抗体 eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages. Post-translational modifications: Highly N-glycosylated. Glycosylation varies between cell types. Similarity: Contains 1 C-type lectin domain. Gene ID: 160364 Database links: Entrez Gene: 160364 Human Omim: 612088 Human SwissProt: Q5QGZ9 Human Unigene: 190519 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
C型凝集素结构域家族12成员A抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞膜受体 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid