谷氨酸脱氢酶2抗体
规格：1mg/1ml
英文名： GLUD2
别名： GDH 2; GDH; GDH2; GLUDP1; Glutamate dehydrogenase 2; Glutamate dehydrogenase 2 mitochondrial; Glutamate dehydrogenase pseudogene 1.
分子量： 111kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GLUD2
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：
谷氨酸脱氢酶2抗体产品介绍：background: GLUD2 is both mitochondrial matrix enzymes belonging to the Glu/Leu/Phe/Val dehydrogenases family. Exisiting as homohexamers, GLUD1 catalyzes the oxidative deamination of glutamate to ?ketoglutarate and ammonia while GLUD2 is involved in the recycling of glutamate during neurotransmission. GLUD1 is critical for regulating amino acid induced insulin secretion and is allosterically activated by ADP and inhibited by GTP and ATP. Mutations in the gene encoding GLUD1 causes hyperinsulinism-hyperammonemia syndrome (HHS), which is an inherited condition characterized by high insulin and ammonia levels in the blood. GLUD1 may also be involved 谷氨酸脱氢酶2抗体in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate. GLUD2 is expressed in testis and retina, with lower levels found in brain. Function: GLUD2, Glutamate dehydrogenase 2, is important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. It is expressed in retina, testis and, at a lower level, brain. Subunit: Interacts with AIP1,谷氨酸脱氢酶2抗体 AP4M1, BECN1, GOPC, GRID2IP, SHANK1 and SHANK2 (By similarity). Subcellular Location: Mitochondrial Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID2 subfamily. Database links: UniProtKB/Swiss-Prot: O43424.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
谷氨酸脱氢酶2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 干细胞 新陈代谢
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid