肽基脯氨酸异构酶酶FKBP25抗体
规格：1mg/1ml
英文名： FKBP25
别名： FKBP 25; FKBP 3; FKBP25; FKBP3; PPIase; Rotamase; FKBP3_HUMAN.
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FKBP25
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
肽基脯氨酸异构酶酶FKBP25抗体产品介绍：background: FKBP25 is a member of the immunophilin protein family. The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs, such as cyclosporin, FK506 and rapamycin. They inhibit T-cell proliferation by interrupting two specific cytoplasmic signal transmission pathways. FKBP25 is localized in the nucleus and is expressed in the brain, testis, ovary, and spleen. It may influence immunoregulation and cerebellum development, as well as protein folding and trafficking in neurons. FKBP25 associates with transcriptional repressor protein YY1 and histone deaceltylases, HDAC1 and HDAC2. FKBP25 may contain several casein kinase II phosphorylation sites, which are believed to be important for cell growth regulation. Function:肽基脯氨酸异构酶酶FKBP25抗体 FK506 binding proteins (FKBPs) are peptidyl proline isomerase enzymes (catalyzing the interconversion of cis-> trans proline in proteins). Cytosolic FKBPs are inhibited by the immunosuppressive drugs FK506 and rapamycin, and regulate calcineurin signalling in T cells. A unique member of the FKBP family is FKBP25 (also known as FKBP3). It is localized to the nucleus, and has been shown to interact 肽基脯氨酸异构酶酶FKBP25抗体with the transcription factor YY1 and HDAC enzymes. These observations suggest that FKBP25 may play a direct role in transcriptional regulation and chromatin modifications. FKBP25 has also been shown to be down-regulated following p53 induction. Subcellular Location: Nuclear Similarity: Belongs to the FKBP-type PPIase family. Contains 1 PPIase FKBP-type domain. Database links: UniProtKB/Swiss-Prot: Q00688.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肽基脯氨酸异构酶酶FKBP25抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid